{"id":3220,"date":"2026-03-03T17:08:18","date_gmt":"2026-03-03T17:08:18","guid":{"rendered":"https:\/\/chennaiexpress.org\/?p=3220"},"modified":"2026-03-03T17:08:20","modified_gmt":"2026-03-03T17:08:20","slug":"mgm-group-hospitals-pioneer-next-gen-cell-based-immunotherapy-offer-new-hope-in-advanced-cancercare","status":"publish","type":"post","link":"https:\/\/chennaiexpress.org\/?p=3220","title":{"rendered":"MGM Group Hospitals Pioneer Next-gen Cell-based Immunotherapy, Offer New Hope in Advanced CancerCare"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"MGM Group Hospitals Pioneer Next-gen Cell-based Immunotherapy, Offer New Hope in Advanced CancerCare\" width=\"1140\" height=\"641\" src=\"https:\/\/www.youtube.com\/embed\/NGSRSSiDOWI?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/chennaiexpress.org\/wp-content\/uploads\/2026\/03\/262fadd4-b9d3-4475-8592-e2dd681dba88-1024x682.jpg\" alt=\"\" class=\"wp-image-3221\" style=\"width:587px;height:auto\" srcset=\"https:\/\/chennaiexpress.org\/wp-content\/uploads\/2026\/03\/262fadd4-b9d3-4475-8592-e2dd681dba88-1024x682.jpg 1024w, https:\/\/chennaiexpress.org\/wp-content\/uploads\/2026\/03\/262fadd4-b9d3-4475-8592-e2dd681dba88-300x200.jpg 300w, https:\/\/chennaiexpress.org\/wp-content\/uploads\/2026\/03\/262fadd4-b9d3-4475-8592-e2dd681dba88-768x512.jpg 768w, https:\/\/chennaiexpress.org\/wp-content\/uploads\/2026\/03\/262fadd4-b9d3-4475-8592-e2dd681dba88.jpg 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Strengthening their position as Centres of Excellence in Precision Oncology in the city, MGM Cancer Institute and MGM Healthcare Malar, Adyar have successfully administered Chimeric Antigen Receptor T-Cell Therapy (CAR-T Cell Therapy), a next-generation cell-based immunotherapy, saving the lives of two elderly patients with aggressive cancers after conventional therapies had failed.<\/p>\n\n\n\n<p>A breakthrough in personalised cancer care, CAR-T Cell Therapy involves engineering a patient\u2019s own immune cells to identify and eliminate cancer cells. The therapy offers new hope for patients with challenging and advanced-stage cancers, particularly those whose disease has relapsed or progressed despite standard therapies.<\/p>\n\n\n\n<p>Among the beneficiaries was a 70-year-old man who had been battling lymphoma, a cancer of the lymphatic system, for over eight months. His treatment was complicated by underlying cardiac issues that limited the use of full-dose chemotherapy. After a relapse left him with very few conventional options, he underwent CAR-T therapy at MGM Healthcare Malar, Adyar.<\/p>\n\n\n\n<p>The second patient, a 62-year-old man, had been diagnosed with refractory Diffuse Large B-Cell Lymphoma, an aggressive and fast-growing form of lymphoma, affecting infection-fighting B cells. He had failed to respond to first-line chemotherapy administered four months earlier, and his prognosis was considered poor due to resistance to standard treatment. He received CAR-T therapy at MGM Cancer Institute.<\/p>\n\n\n\n<p>In his comments Dr. M.A Raja, Director and Senior Consultant, Medical Oncology, MGM Cancer Institute, said, \u201cPrecision oncology continues to create newer, biology-driven treatment pathways tailored to each individual. Even advanced-stage cancers need not mean the end of options. In our hospitals, the CAR-T program has been developed with a strong emphasis on customised care, patient safety, and financial responsibility. By using optimal insurance utilisation, and judicious avoidance of ICU admission wherever clinically appropriate, our team delivered this complex therapy in a cost-effective and sustainable manner, making it more accessible to patients.\u201d<\/p>\n\n\n\n<p>In his comments, Dr. M. Gopinathan &#8211; Consultant, Hemato-Oncology (BMT), MGM Cancer Institute, said, \u201cThis technology works by rebooting the patient\u2019s own immune system. T cells are collected from the patient\u2019s blood through a specialised process and sent to an advanced laboratory, where they are carefully reprogrammed to recognise and attack cancer cells. After thorough quality checks, the modified cells are returned to the hospital and infused back into the patient to fight the disease. This form of cellular therapy represents a major advancement in modern blood cancer treatment.\u201d<\/p>\n\n\n\n<p>He added that the transplant physician customises chemotherapy for each patient and ensures the primary disease is adequately controlled before the CAR-T cells are infused. This process requires a well-equipped apheresis centre, where blood is processed to collect only the required component while safely returning the rest to the body, along with an advanced GMP-certified laboratory and a dedicated intensive care unit to deliver seamless, end-to-end care. Robust logical support with adequate maintenance of temperature is needed when we do transfer of cells between laboratories. The research improvisations with CART production and delivery are constantly evolving over time, to reduce side effects, and in future, expanded access to their use in autoimmune disorders is just a footstep away.<\/p>\n\n\n\n<p>Dr. Suman Kalyan. N, Senior Consultant \u2013 Medical Oncology and Director, CAR-T Program, MGM Healthcare Malar, Adyar, said, \u201cEvery patient is different, and every cancer behaves differently. That is why precision oncology is the future of cancer care. With CAR-T and advanced molecular therapies, we can now personalise treatment even in complex and advanced cases.\u201d<\/p>\n\n\n\n<p>Harvard-certified in Precision Oncology, Dr. Suman Kalyan. N has led the development of India\u2019s first structured, cost-effective CAR-T protocols, comprising insurance-supported pathways, making advanced cellular therapy feasible for a broader population. \u201cThese protocols are designed not only for Indian patients, but also for international patients seeking high-quality, affordable cancer care &#8211; reinforcing Chennai\u2019s long-standing reputation as the capital of global health tourism,\u201d he added.<\/p>\n\n\n\n<p>The success of the programme reflects the strength of a fully integrated, in-house multidisciplinary team at MGM Healthcare hospitals, bringing together expertise from oncology, transfusion medicine, nursing, pharmacy and<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Strengthening their position as Centres of Excellence in Precision Oncology in the city, MGM Cancer Institute and MGM Healthcare Malar, Adyar have successfully administered Chimeric Antigen Receptor T-Cell Therapy (CAR-T Cell Therapy), a next-generation cell-based immunotherapy, saving the lives of two elderly patients with aggressive cancers after conventional therapies had failed. A breakthrough in personalised [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3221,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[8],"tags":[],"class_list":["post-3220","post","type-post","status-publish","format-image","has-post-thumbnail","hentry","category-commercial","post_format-post-format-image"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/chennaiexpress.org\/wp-content\/uploads\/2026\/03\/262fadd4-b9d3-4475-8592-e2dd681dba88.jpg","jetpack_sharing_enabled":true,"jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":2977,"url":"https:\/\/chennaiexpress.org\/?p=2977","url_meta":{"origin":3220,"position":0},"title":"MGM Cancer Institute Illuminates World Rose Day","author":"CHENNAI EXPRESS","date":"September 27, 2025","format":"image","excerpt":"https:\/\/youtu.be\/DfbHq1LUS5o MGM Cancer Institute Illuminates World Rose Day with a Celebration of Courage, Hope, and HealingChennai, September 24, 2025: MGM Cancer Institute transformed World Rose Day into a moving celebration of life, resilience, and the unshakable power of the human spirit. 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The\u2026","rel":"","context":"In &quot;Commercial&quot;","block_context":{"text":"Commercial","link":"https:\/\/chennaiexpress.org\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/chennaiexpress.org\/wp-content\/uploads\/2025\/11\/d18d86d4-b50b-4c2f-a220-87fd26c05c49.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":2767,"url":"https:\/\/chennaiexpress.org\/?p=2767","url_meta":{"origin":3220,"position":3},"title":"MGM Cancer Institute Performs Complex Bone Marrow Transplant to Cure Rare Genetic Immunodeficiency in 33-Year-Old Woman","author":"CHENNAI EXPRESS","date":"July 24, 2025","format":"image","excerpt":"MGM Cancer Institute Performs Complex Bone Marrow Transplant to Cure Rare Genetic Immunodeficiency in 33-Year-Old Woman https:\/\/youtu.be\/CRnYz4GsjVI Chennai, 23rd July 2025: MGM Cancer Institute successfully performed a life-saving bone marrow transplant (BMT) on 33-year-old Ms. Janani, who was diagnosed with GATA2 primary immunodeficiency, a rare genetic disorder that weakens the\u2026","rel":"","context":"In &quot;Commercial&quot;","block_context":{"text":"Commercial","link":"https:\/\/chennaiexpress.org\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/chennaiexpress.org\/wp-content\/uploads\/2025\/07\/WhatsApp-Image-2025-07-23-at-5.20.36-PM-scaled.jpeg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":3266,"url":"https:\/\/chennaiexpress.org\/?p=3266","url_meta":{"origin":3220,"position":4},"title":"MGM Healthcare Malar, Adyar Removes Congenital Lung Defect in One-Year-Old Using Minimally Invasive Surgery","author":"CHENNAI EXPRESS","date":"March 17, 2026","format":"image","excerpt":"MGM Healthcare Malar, Adyar Removes Congenital Lung Defect in One-Year-Old Using Minimally Invasive Surgery Chennai, March 17 2026: MGM Healthcare Malar, Adyar has successfully performed a Video-Assisted Thoracoscopic Surgery (VATS), a minimally invasive procedure, on a one-year-old girl to remove a congenitally developed non-functional portion of the lung (the lower\u2026","rel":"","context":"In &quot;Commercial&quot;","block_context":{"text":"Commercial","link":"https:\/\/chennaiexpress.org\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/chennaiexpress.org\/wp-content\/uploads\/2026\/03\/WhatsApp-Image-2026-03-17-at-7.29.10-PM.jpeg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":3316,"url":"https:\/\/chennaiexpress.org\/?p=3316","url_meta":{"origin":3220,"position":5},"title":"MGM Healthcare Sets Up World\u2019s Largest Intestinal Rehab &amp; Transplant Program in Chennai in Three Years","author":"CHENNAI EXPRESS","date":"March 27, 2026","format":"image","excerpt":"MGM Healthcare Sets Up World\u2019s Largest Intestinal Rehab & Transplant Program in Chennai in Three Years Chennai, March 26, 2026: MGM Healthcare, a leading quaternary care hospital in Chennai, has built the world\u2019s largest intestinal rehabilitation and transplant program from scratch in a record three years. 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