{"id":2767,"date":"2025-07-24T13:01:55","date_gmt":"2025-07-24T13:01:55","guid":{"rendered":"https:\/\/chennaiexpress.org\/?p=2767"},"modified":"2025-07-24T13:01:57","modified_gmt":"2025-07-24T13:01:57","slug":"mgm-cancer-institute-performs-complex-bone-marrow-transplant-to-cure-rare-genetic-immunodeficiency-in-33-year-old-woman","status":"publish","type":"post","link":"https:\/\/chennaiexpress.org\/?p=2767","title":{"rendered":"MGM Cancer Institute Performs Complex Bone Marrow Transplant to Cure Rare Genetic Immunodeficiency in 33-Year-Old Woman"},"content":{"rendered":"\n<p>MGM Cancer Institute Performs Complex Bone Marrow Transplant to Cure Rare Genetic Immunodeficiency in 33-Year-Old Woman<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"MGM Cancer Institute Performs Complex Bone Marrow Transplant to Cure Rare Genetic Immunodeficiency\" width=\"1140\" height=\"641\" src=\"https:\/\/www.youtube.com\/embed\/CRnYz4GsjVI?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>Chennai, 23rd July 2025: MGM Cancer Institute successfully performed a life-saving bone marrow transplant (BMT) on 33-year-old Ms. Janani, who was diagnosed with GATA2 primary immunodeficiency, a rare genetic disorder that weakens the immune system by impairing the production of essential blood and immune cells.<\/p>\n\n\n\n<p>Bone marrow transplant (BMT) is the only definitive cure for GATA2 primary immunodeficiency, a condition that, if left untreated, can significantly increase the risk of developing serious bone marrow diseases such as myelodysplastic syndrome (MDS), a disorder in which the marrow produces poorly formed or dysfunctional blood cells or acute myeloid leukemia (AML), an aggressive cancer marked by the rapid growth of abnormal white blood cells in the blood and bone marrow.<\/p>\n\n\n\n<p>Despite experiencing severe infection and gut-related complications during the transplant process, Ms. Janani responded well to intensive care, achieved timely engraftment, the point at which the newly transplanted stem cells begin producing healthy blood cells, and made a full recovery, returning to normal life just three months after the procedure.<\/p>\n\n\n\n<p>In his comments, Dr. Gopinathan, Consultant, Hemato-Oncology, MGM Cancer Institute, who led the procedure, said, \u201cThis patient had been living with GATA2-related primary immunodeficiency for nearly 24 years, enduring recurrent infections throughout her life. Bone marrow transplantation is the only definitive cure for this condition, but achieving success requires a highly individualised approach, especially in complex cases. In her case, we performed a half-matched (haploidentical) transplant, where the donor shared only 50% of her genetic profile. Such procedures are technically demanding and require precise immune modulation to ensure successful engraftment and avoid serious complications. Adding to the complexity, she also had pulmonary alveolar proteinosis restricting her lung functions and disseminated non tubercular mycobacterial infection. These factors made the transplant significantly more challenging, particularly when it came to administering chemotherapy, which had to be carefully tailored due to her compromised lung function\u201d.<\/p>\n\n\n\n<p>In his comments, Dr. M.A. Raja, Director and Senior Consultant, Medical Oncology, MGM Cancer Institute, said, \u201cGATA2 immunodeficiency is an exceptionally rare form of primary immunodeficiency, especially in adults, with only about 2% of cases presenting in adulthood. It is scarcely documented in medical literature and is known for its highly variable. Due to its progressive nature, early diagnosis is often difficult but critical. Research indicates that approximately 70% of individuals with GATA2 mutations eventually go on to develop myelodysplastic syndrome or acute myeloid leukemia. Therefore, bone marrow transplantation is crucial as a potential cure, and it reduces the long-term risk of malignant transformation.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>MGM Cancer Institute Performs Complex Bone Marrow Transplant to Cure Rare Genetic Immunodeficiency in 33-Year-Old Woman Chennai, 23rd July 2025: MGM Cancer Institute successfully performed a life-saving bone marrow transplant (BMT) on 33-year-old Ms. Janani, who was diagnosed with GATA2 primary immunodeficiency, a rare genetic disorder that weakens the immune system by impairing the production [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2768,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[8],"tags":[1288,1289,1290,1287,1291],"class_list":["post-2767","post","type-post","status-publish","format-image","has-post-thumbnail","hentry","category-commercial","tag-bone-marrow-transplant","tag-genetic-immunodeficiency","tag-mgm","tag-mgm-cancer-institute","tag-mgm-health","post_format-post-format-image"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/chennaiexpress.org\/wp-content\/uploads\/2025\/07\/WhatsApp-Image-2025-07-23-at-5.20.36-PM-scaled.jpeg","jetpack_sharing_enabled":true,"jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":3220,"url":"https:\/\/chennaiexpress.org\/?p=3220","url_meta":{"origin":2767,"position":0},"title":"MGM Group Hospitals Pioneer Next-gen Cell-based Immunotherapy, Offer New Hope in Advanced CancerCare","author":"CHENNAI EXPRESS","date":"March 3, 2026","format":"image","excerpt":"https:\/\/youtu.be\/NGSRSSiDOWI Strengthening their position as Centres of Excellence in Precision Oncology in the city, MGM Cancer Institute and MGM Healthcare Malar, Adyar have successfully administered Chimeric Antigen Receptor T-Cell Therapy (CAR-T Cell Therapy), a next-generation cell-based immunotherapy, saving the lives of two elderly patients with aggressive cancers after conventional therapies\u2026","rel":"","context":"In &quot;Commercial&quot;","block_context":{"text":"Commercial","link":"https:\/\/chennaiexpress.org\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/chennaiexpress.org\/wp-content\/uploads\/2026\/03\/262fadd4-b9d3-4475-8592-e2dd681dba88.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":2977,"url":"https:\/\/chennaiexpress.org\/?p=2977","url_meta":{"origin":2767,"position":1},"title":"MGM Cancer Institute Illuminates World Rose Day","author":"CHENNAI EXPRESS","date":"September 27, 2025","format":"image","excerpt":"https:\/\/youtu.be\/DfbHq1LUS5o MGM Cancer Institute Illuminates World Rose Day with a Celebration of Courage, Hope, and HealingChennai, September 24, 2025: MGM Cancer Institute transformed World Rose Day into a moving celebration of life, resilience, and the unshakable power of the human spirit. 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The felicitation ceremony was attended by MLA Mr. M.K.\u2026","rel":"","context":"In &quot;Commercial&quot;","block_context":{"text":"Commercial","link":"https:\/\/chennaiexpress.org\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/chennaiexpress.org\/wp-content\/uploads\/2025\/08\/6ced2e9f-433a-41ed-a3e0-88e207b7e3df.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":3048,"url":"https:\/\/chennaiexpress.org\/?p=3048","url_meta":{"origin":2767,"position":3},"title":"Over 1,000 Participants Come Together for MGM Cancer Institute\u2019s Walkathon for Breast Cancer Awareness","author":"CHENNAI EXPRESS","date":"November 3, 2025","format":"image","excerpt":"https:\/\/youtu.be\/c6cHX0YM3jE Over 1,000 Participants Come Together for MGM Cancer Institute\u2019s Walkathon for Breast Cancer Awareness Chennai, November 2, 2025: MGM Cancer Institute hosted \u201cWalk in Pink\u201d, a walkathon to raise breast cancer awareness, attracting over a thousand participants, including hospital staff, healthcare professionals, and students from across the city. 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